Powerful probiotic lozenges support your nose, throat, and oral health

Probiotic Advantage Oral Sinus (50 lozenges) | Oral Sinus Probiotics

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Buy 3, Get 1 FREE
Was: $99.96
Now: $74.97
Buy 5, Get 2 FREE
Was: $174.93
Now: $124.95

Probiotic Advantage Oral Sinus lozenges deliver year-round oral and sinus support right where you need it most

  • Promotes healthy bacterial balance in the oral and sinus regions
  • Supports a healthy immune system
  • Helps keep your teeth, gums, throat, and sinuses healthy
  • Promotes fresh breath

Probiotic Advantage Oral Sinus contains 3 unique strains of healthy bacteria that help to keep your teeth, gums, and entire respiratory system healthy.

In one clinical study, S. salivarius K12 was shown to help promote throat, pharynx, and ear health in children.1

In a separate clinical study, S. salivarius K12 promoted a healthy environment for the throat and pharynx in adults when taken on a daily basis.2

Additionally, in a trial of 23 subjects, 85% of those taking S. salivarius K12 for 2 weeks, compared to 30% of those taking a placebo, had a significant reduction in the foul-smelling chemicals that cause bad breath.3

  1. Streptococcus salivarius K12 generates 2 protective proteins—Salivaricin A and Salivaricin B—which help promote a healthy balance of bacteria.
  2. Streptococcus salivarius M18 contains 2 enzymes that support healthy teeth and gums. In a placebo-controlled clinical study, children taking S. salivarius M18 had improvement in an important marker of dental health.
  3. L. reuteri has been shown to support healthy teeth, mouth, and gums.

Plus, you get vitamin D and zinc to help support your immune system.

I take Probiotic Advantage Oral Sinus every day and suggest you do so as well.

1 Di Pierro F, et al. Int J Gen Med. 2012;5:991–97.
2 Di Pierro F, et al. Expert Opin Biol Ther. 2013;13(3):339–43.
3 Burton JP, et al. J Appl Microbiol. 2006; 100:754–64.

Ingredients and Dosage

Doctor’s Suggested Use: Adults and children 4 and older: Dissolve 1 lozenge in mouth once or twice daily, preferably after brushing teeth and/or mouthwash, and then swallow.

Serving Size: 1 lozenge
Servings Per Container: 50

Ingredient Amount Per Serving % DV
Vitamin D (as cholecalciferol) 400 IU 100%
Zinc (as oxide) 5 mg 33%
Oral Probiotic Blend L. reuteri, S. salivarius K12, S. salivarius M18 40 mg *
*Daily Value (DV) not established.

Other ingredients: Isomalt, microcrystalline cellulose, stearic acid, dicalcium phosphate, cinnamon flavor (natural), stevia, vanilla flavor (natural)
CONTAINS: MILK (Product may contain trace amounts of milk from fermentation process.)

Note: Pregnant or lactating women should consult a health care professional before taking this product.
Keep out of reach of children.

Contains one billion live bacteria when manufactured and provides an effective level until at least the expiration date.

Batch Information

Science and Quality

S. salivarius K12

In a study of 150 subjects, those taking S. salivarius K12 showed improvements in dental health.

In a study of 9 children, those taking oral S. salivarius K12 for 6 months exhibited better ear health.

A small study of 5 subjects found that within 24 hours of taking S. salivarius K12, immune markers increased.  Ingestion of the strain has been found to increase levels of interferon gamma in saliva, which suggests an enhanced immune response.

 S. salivarius M18

In a placebo-controlled clinical study, 83 children between the ages of 5 and 10 took part in a 90-day treatment protocol analyzing the effects of M18 on plaque and S. mutans counts. Children in both the placebo and treatment group (2x/d lozenges with 3.5 billion CFU of M18) received cleaning procedures at the start of study, removing any plaque.

Note: the version of M18 used in this study was a very early commercial form with a 20% colonize rate. Current versions have been optimized to colonization rates to >90% at only 1 billion CFU/day. Even with this early version, beneficial effects were still seen. 

At 90 days, 44% of kids in the control group had a 3 point improvement in oral health, while the M18 treatment group had 88% of kids with improvement. The other 12% of the kids did not have successful colonization of M18. In the kids where M18 did colonize, there was a 100% improvement. 

This distinctive strain is shown to promote healthy teeth and gums.

L. reuteri

L. reuteri is thought to be capable of promoting dental health by reducing unbeneficial bacterium.

A double-blind, placebo-controlled trial showed that consuming L. reuteri in yogurt compared with placebo yogurt and yogurt containing other lactobacilli strains helped maintain a normal level of healthy oral bacteria as well as helped prevent non-beneficial bacteria from occupying the oral cavity.
In a randomized, placebo-controlled, double-blind study, 59 subjects were given 200 Million CFU/day or placebo over 2 weeks. Results: 

  • Oral health scores increased for individuals consuming L. reuteri while there was no significant change in the placebo group.
  • L. reuteri helped maintain a normal level of healthy oral bacteria, as well as helped prevent non-beneficial bacteria from occupying the oral cavity.
  • L. reuteri helped support a healthy oral environment.

Vitamin D

Vitamin D plays a role in blood cell formation and it increases the activity of natural killer cells and T cells, supporting the immune system.


 Zinc is an essential mineral that plays a role in over 200 different enzymatic reactions, mostly involving the structure of the body.

Product Quality

  • Manufactured to exacting standards using highest quality raw materials
  • Produced in accordance with our strict Standard Operating Procedures (SOPs) that meet or exceed those set by the FDA’s Good Manufacturing Practices
  • Every batch tested to verify purity and potency specifications are met
  • Details of specific product testing is listed in the Certificate of Quality
  • Quality assured with our Triple-Testing Philosophy™
  • Backed by our 100% satisfaction guarantee