Rub away pain from sprains, strains, arthritis, bursitis, and more!

OxyRub Pain Relief Cream, 4 oz. | Joint, Muscle & Arthritis Pain Relief Cream

Item# OXY
1 Bottle, SAVE $20.00
Was: $39.99
Now: $19.99
3 Bottles, SAVE $65.00
Was: $119.97
Now: $54.97
6 Bottles, SAVE $140.00
Was: $239.94
Now: $99.94

Clinically shown to provide TWICE as much
pain relief as the leading pain cream

Pain is the single most common reason that patients seek medical care—and yet, there have been shockingly few truly effective solutions.  NOT ANYMORE.  Whether you’ve been fighting arthritis pain for ages or just suffer from aches and pains after a round of golf or an afternoon in the garden, OxyRub can eliminate your pain—quickly.

OxyRub combines the pain-relieving power of menthol with a proprietary oxygenated essential oil into a soothing, pleasant-smelling cream.  Every drop works on contact to:

  • Dissolve arthritis pain in knees, hips, fingers, and wrists
  • Relieve tense, painful back, leg, and neck muscles
  • Cool and soothe stubborn bursitis pain
  • Take the throbs out of bumps, sprains, and bruises

And so much more…

Just apply OxyRub where it hurts and PRESTO! No more pain!

That’s because OxyRub rubs in quickly and goes to work right at the source of your pain, to conquer it almost instantly, right on contact.

Without waiting to digest a pill…without worrying about drug interactions or harmful side effects…without medicinal scents, messy oils or greasy lotions.

OxyRub’s secret lies in a proprietary blend of menthol, emollients, and oxygenated essential oil in a soothing, non-greasy cream that’s absorbed into the skin in seconds with NO burning or irritation!

Clinical studies prove

In a double-blind, randomized, controlled head-to-head study, OxyRub was put to the test against a leading, mainstream menthol-only cream. After 8 days, users reported their acute pain decreased by an impressive 27.8% compared to just 13.7% in the menthol-only group. That’s MORE THAN DOUBLE the effectiveness of the leading mainstream pain cream!

Users also reported a 59.9% improvement in mobility and flexibility compared to just 34.4% in the menthol-only group.

Many users reported relief in as little as 30–45 seconds…with increased pain-relieving power over the next 30 minutes and lasting for hours at a time. PLUS, OxyRub continues to work better the longer you use it!  

Developed by one of the world’s most renowned pain specialists!

As you can see, OxyRub is no ordinary pain reliever.  And with good reason. It was developed by renowned pain specialist, Dr. Joseph Pergolizzi. If you search the globe, you’ll find almost no one as knowledgeable about pain and pain management as Dr. Pergolizzi.

Dr. Pergolizzi’s clinical experience with suffering patients combined with his extensive firsthand research into the most effective ways to control or eliminate pain led to a startling discovery:

“I was seeing patients enduring terrible chronic pain—some for as long as 12 years—without effective relief! I knew there had to be a better solution, and I refused to stop searching until I found it.”
—Dr. Joseph Pergolizzi

And that’s just what he did. Dr. Pergolizzi set out to create OxyRub. A safe, natural, powerful pain-relieving product that:

  • Works quickly and is long-lasting
  • Can be used as often as needed
  • Is effective and affordable
  • Is free of any negative side effects, with no drug interactions
  • And is available without a prescription

So why wait? Don’t let arthritis…bursitis…muscle pulls…back, knee, neck pain…hold you back from the life you love. Wipe out your pain, on contact. Feel your pain vanish!

Try OxyRub for yourself today absolutely risk-free. And if you don’t believe that it isn’t TWICE AS POWERFUL as any other pain reliever, simply send it back for a full refund.

*Individual results will vary.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Ingredients & Dosage

Active Ingredient: Menthol (1.25%)..................................................Topical Analgesic

Directions: Adults and children 12 years of age and older, Apply to affected area no more than 3-4 times daily. Children under 12 years of age, consult a doctor before use.

Recommended uses:Temporarily relives minor aches and pains of muscles and joints associated with simple backaches, arthritis, strains, sprains, bruises.

Warnings: For external use only.  Use only as directed.  Avoid contact with eyes or broken skin.  Do not bandage tightly. Do not use with a heating pad, it may blister skin.

Ask a doctor before use if you have redness over the affected area.

Stop use and consult a doctor if skin redness or excessive skin irritation develops; condition worsens or symptoms persist for more than 7 days; symptoms clear up and occur again in a few days.

Keep out of reach of children.  If swallowed, get medical help or contact a Poison Control center right away.

Other information: Store at room temperature. For Lot Number and Expiration Date, see crimp at the end of the tube.

Inactive Ingredients: Bitter Orange Oil, C13-14 Isoparaffin, Caprylhydroxomic Acid, Caprylyl Glycol, Eucalyptus Oil, Glycerin, Laureth-7, Oxidized Corn Oil, Polyacrylamide (1000 MW), Polysorbate 20, Water


Displaying 1-4 of 4


Reviewed on
5.0 out of 5 stars

I have been suffering with [pain] for several weeks. No pain relief what so ever. No sleep. Dr throwing muscle relaxers at me. Knocked me out, however that excruciating pain in lower nack and all the way down my left leg to my foot. When this amazing OxyRub arrived, I thought this is my last hope for relief. I rubbed it across my lower back and leg. Oh my God it was such a wonderful feeling. Finally RELIEF! I will never be without this OxyRub cream. It also leaves your skin soft. Love love love my OxyRub. Thank you for discovering and manufacturing OxyRub. I don't know how it works, I just know it does.


Reviewed on
5.0 out of 5 stars

My daughter recommended I try OxyRub when I mentioned the chronic pain I have developed in the fingers of my right hand. I assumed it was joint pain or computer-related over-use ... but as a "youngish-50-plus" year-old, I hadn't bothered to deal with it! So, I was happily surprised when the OxyRub worked! It was like magic ... in a few minutes, I flexed my thumb and realized ... the pain was gone!! I'll definitely be recommending OxyRub to all my friends, and I'll bring it with me to show my internist at my next check-up.


Reviewed on
5.0 out of 5 stars

I am a dancer and had undergone several leg injuries over the course of many years (sprained ankles, fractured foot, hamstring injury). Due to multiple injuries, when I work out at the gym, often times, my legs can get extremely sore or the old pain returns. I had tried everything from pain medication to trigger injections to steroid creams, and I was seeking a cream that did not have long-term consequences. Within a night’s worth of rubbing the cream into my muscles, I was feeling pain relief. Over the course of a few days, the pain was completely gone. I was able to start working out again without having to worry about pain. Nothing could slow me down! The immediate cooling sensation is extremely soothing and the fact that the smell is not strong and evaporates shortly after applying to skin is a bonus.


Reviewed on
5.0 out of 5 stars

Over a 50 yr. period I have tried scores of topical applications for pain. OxyRub sounded too good to be true, but when I tried I found it was amazingly TRUE! It is not greasy, nor smelly. It doesn't take a lot and absorbs well and it is very effective! It is worth your time, money and effort to give it a try if you need pain relief.

Science & Quality

A high-quality source for pain relief

OxyRub harnesses the soothing power of menthol (a proven OTC pain reliever) in combination with essential oxygen oils for fast-acting, long-lasting pain relief. This exclusive combination of ingredients provides joints and muscles with reprieve from aches and strains, and even the pain of arthritis.  

In a double-blind, randomized, controlled head-to-head study, OxyRub Pain Relief Cream was tested against today’s leading menthol-only pain cream. By day eight of the treatment, acute pain in OxyRub users had decreased by double that of those using the leading pain-relief cream. During the study, limitation of activity decreased by 59.9% for OxyRub users, compared to 34.4% for the menthol-only group.

Essential Oils & Ancient Practices

How oil, oxygen, and sunshine soothe skin

In the 1950’s and 60’s, Professor Pierre Baranger—a member of the Pasteur Institute’s scientific team—traveled throughout India studying the healing powers of chaulmoogra oils. These oils were known throughout the East for their exceptional restorative virtues, including relief from joint, muscle, tendon, and even bone aches.

Upon further study into the healing qualities of chaulmoogra, Baranger became perplexed as to why modern doctors in the mainland cities weren’t using the oils. Local healers informed him that it was because modern doctors didn’t know the secret to properly preparing the oils. To truly harness its natural healing powers, the oil first had to be exposed to sun and open air for 20 years. Using all he had learned from the medicine men of India, Baranger was able pioneer a process that replicates 20 years of oxygenation in just three days. This allowed him to introduce these powerful soothing oils to the West.

Dr. Pergolizzi was first introduced to the benefits of oxygenated oil while traveling through Germany. During his time abroad he spoke to an Olympic trainer whose athletes were rubbing oxygenated oil onto their muscles to relieve aches and pains. This inspired Dr. Pergolizzi to learn more about oxygenated oil, the history of its use, and how he could best incorporate it into his own pain-relief treatments.

Dr. Pergolizzi’s OxyRub utilizes the therapeutic features of vegetable oil via oxygenation and sun exposure. The mixture of sun and air changes the molecular structure of the oil, unlocking a world of potential for both soothing and moisturizing skin.

Product Quality

  • Manufactured to exacting standards using highest quality materials
  • Produced under our own SOPs that meet or exceed FDA GMPs
  • Every batch tested to verify purity and potency specifications are met
  • Specific product testing is listed in the Certificate of Quality
  • Quality assured with our Triple-Testing Philosophy™
  • Backed by our 100% satisfaction guarantee