Fast-acting, botanical mood enhancer and stress reliever

ZemBright Mood Plus (30 capsules, 1-month supply) | Mood Enhancing & Ashwagandha Supplements

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Buy 3, Get 1 FREE
Was: $139.96
Now: $104.97
Buy 5, Get 2 FREE
Was: $244.93
Now: $174.95

ZemBright Mood Plus® is a mood-enhancing supplement that helps reduce stress and keep you focused:

  • Lowers cortisol levels to ease feelings of stress
  • Promotes positive mood and outlook
  • Supports healthy brain and nerve function
  • Improves focus, alertness, and sense of calm
  • Non-habit forming, non-drowsy

This ancient South African remedy is a fantastic, mood-enhancing supplement

My years-long search for natural, effective ways to balance mood and improve the way our bodies respond to stress recently led me to Zembrin®—a patented extract known by the San people of South Africa as "kanna" (Sceletium tortuosum).

The native San tribesmen there have used it for centuries to increase energy, elevate mood, and soothe the effects of stress. Traditionally, kanna was chewed or smoked, but Zembrin is a patented, powdered form of kanna extract, developed after 12 years of meticulous research. The extract contains a mix of the most desirable active compounds of the plant and is standardized in a way that produces consistent and noticeable results in everyone tested.

I started taking Zembrin myself during a difficult period in my life and was incredibly impressed with the effects. It helped me feel happier and more relaxed…yet attentive, alert, and motivated, too!

Specifically, Zembrin helps increase levels of serotonin and enhance serotonin neurotransmission. This is important because serotonin is your body's natural "feel good" hormone.

Zembrin is particularly helpful if you're feeling edgy, anxious, or simply overwhelmed by everyday stress. And you can quickly feel the effects!

In a 2013 double-blind, placebo-controlled study, participants took 25 mg of Zembrin. Two hours later they underwent MRI brain scans while completing performance tests that introduced fear/anger/threat emotions. Results showed that just this single dose of Zembrin quickly helped the brain react more calmly to stressful stimulants, allowing participants to better cope with stress.1

Non-habit forming and non-drowsy

Better yet, in all studies on Zembrin, participants have reported NO side effects and NO evidence of tolerance. It's a unique, potent mood-enhancing supplement that is non-addictive and non-drowsy.

ZemBright Mood Plus also contains ashwagandha to better balance mood and ease feelings of stress

I added KSM-66® ashwagandha to the Zembrin in my ZemBright Mood Plus for extra-strength, stress-busting support. Ashwagandha comes from a small, woody shrub in the Solanaceae family that's found throughout India. It's been used for thousands of years in traditional medicine and Ayurveda to help bring the body into balance—especially when under stress.

KSM-66 is a remarkable full-spectrum, root-only ashwagandha extract. I insisted on this specific form because it maintains the natural balance of the herb's original constituents, which I believe will give you the best results. In fact, KSM-66 ashwagandha extract won the Best Botanical Ingredient Award for 2013 and placed in the list of top 10 ingredients by editors of Functional Ingredients.

In a double-blind, randomized, placebo-controlled trial, subjects taking KSM-66 had a 27.9% reduction in levels of cortisol—a primary stress hormone—after 60 days, while placebo had a 7.9% reduction. Subjects were then given well-recognized psychological questionnaire tests to measure the effect of KSM-66. Test scores showed a significant 44% reduction in stress and a tremendous 75.6% reduction in anxiousness!2

Works along 3 different pathways for comprehensive mood and stress response support

With the addition of ashwagandha, ZemBright Mood Plus brings you a unique botanical combination that works along 3 distinct pathways for exceptional mood-enhancing support. Here's how…

Pathway #1: Ashwagandha helps lower levels of cortisol, your body's primary stress hormone, to reduce feelings of stress and occasional anxiety, as well as promote a positive mood and mental outlook.

Pathway #2: Zembrin acts as a serotonin reuptake inhibitor (SRI), making more of this "feel good" hormone available for neurotransmission and use by your body.

Pathway #3: Zembrin also works to make more cyclic AMP (or cAMP) messenger chemicals available to your nervous system, which helps improve alertness and cognitive functions under stressful conditions.

Plus, active B vitamins for optimal nerve transmission and serotonin synthesis

I also included a trio of active B vitamins—B6, B12, and a special 4th generation of folate called Quatrefolic®—in my ZemBright Mood Plus formula. These powerful nutrients are essential for the synthesis of serotonin and are also known to support healthy nerve transmission. In addition, they promote normal homocysteine levels for optimal cognitive function.

Survey Results
ZemBright Mood Plus works in 3 ways Endorsed by the South African San Council

1 Terburg D, et al. Neuropsychopharmacology. 2013;38(13):2708–16.
2 Chandrasekhar K, et al. Indian J Psychol Med. 2012;34(3):255–62.

Survey Results
ZemBright Mood Plus works in 3 ways Endorsed by the South African San Council

Ingredients and Dosage

Doctor's Suggested Use: Take 1 capsule daily with a meal.

Serving Size: 1 Capsule
Servings Per Container: 30

Ingredient Amount Per Serving % DV
Vitamin B6 (as pyridoxine HCl, pyridoxine-5-phosphate) 15 mg 750%
Folate (as Quatrefolic®‡ [6S]-5-methyltetrahydrofolic acid glucosamine salt) 100 mcg 25%
Vitamin B12 (as methylcobalamin) 200 mcg 3,333%
KSM-66®§ Ashwagandha Extract (root) 600 mg *
Zembrin®♦ (Sceletium tortuosum extract, stem, and leaf) 25 mg *
* Daily Value (DV) not established

Other ingredients: Gelatin, microcrystalline cellulose, magnesium stearate, silicon dioxide, carmine (as a color additive)
CONTAINS: MILK. (KSM-66® Ashwagandha is prepared in accordance with Ayurvedic tradition resulting in trace quantities of milk remaining in the product).

Note: Pregnant or lactating women should consult a health care professional before taking this product.
Keep out of reach of children.

® is a registered trademark of Gnosis S.p.A. and protected by US Patent No. 7,947,662.

§KSM-66® is a registered trademark of Ixoreal Biomed Pvt. Ltd.

is a registered trademark of HG&H Pharmaceuticals Pty Ltd., exclusively distributed in the USA by PLT Health Solutions, Inc. U.S. Patents #6,288,104 and #8,552,051.

Batch Information

Science and Quality

Traditional Use of Sceletium

Plants of the genus Sceletium were used for relief of thirst and hunger, to combat fatigue, as medicines, and for social and spiritual purposes by the San hunter-gatherers (historically referred to as Bushmen) and Khoi pastoralists (historically referred to as Hottentots) for millennia before the earliest written reports of the uses of the these plants by European explorers and settlers.1

Also called kanna, channa, or kougoed, Sceletium has been used by the indigenous San people for relaxation, stress relief, to promote sleep, and even to soothe colicky and teething infants for thousands of years. There is no documented or oral evidence that its use causes tolerance or addiction, and there is no withdrawal during periods of scarcity.

Since 1685, European settlers have recorded the use of Sceletium, calling it a "restorative, cheerer of the soul," a "good sedative," a calming herb, and (an herb or plant) that elevates mood and decreases anxiety, stress, and tension.


Zembrin is a standardized extract produced from an in-house elite proprietary plant selection of Sceletium tortuosum and contains a mix of the most desirable active compounds based on 12 years of research and development. Zembrin is standardized to 4 major alkaloids.

In vitro studies show potential mechanisms for how Sceletium may be used in products for stress, anxiety, and mood and may also provide a rationale for the apparent lack of dependence seen with long-term Sceletium use. Sceletium has been shown to act as a PDE4 inhibitor and as a serotonin-uptake inhibitor.2

Serotonin is one of the major neurotransmitters in the body. It plays an important role in sleep, pain thresholds, blood clotting, heartbeat, blood vessel constriction, libido, hunger/satiety, and mood. There are 17 types of serotonin receptors found all over the body, each causing different biological effects.

Serotonin reuptake inhibitors block the action of the serotonin transporter, increasing intracellular levels of serotonin and increasing serotonin neurotransmission. Specific constituents of Zembrin are known serotonin reuptake inhibitors (SRIs), which explains the traditional use of Zembrin as a mood lifter.

A randomized, double-blind, placebo-controlled crossover clinical study examined how Zembrin can help manage the stresses of everyday life by enhancing cognitive function.

  • 20 healthy adults were used in the study. They were divided into two groups: Placebo or Zembrin. They were given 25 mg of Zembrin or a placebo daily for 3 weeks. Then they had a 3-week washout period (no capsules). Then the groups were switched and given either placebo or Zembrin for 3 weeks.
  • The CNS VitalSign® test was used to evaluate 10 different types of neuropsychological behavior at the end of each 3 weeks of treatment.
  • There were no side effects. No nausea or vomiting and no elevated pulse, blood pressure, or body weight.
  • The subjects taking Zembrin had significant changes (compared to placebo) in 3 out of the 10 CNS VitalSign® tests: cognitive set flexibility, executive function, and processing speed.
    • Cognitive set flexibility = being able to adapt rapidly to changing directions and use the information given intelligently. This is necessary in decision-making, impulse control, and planning/strategizing.
    • Executive function = exercising initiative, judgment, and discipline. This is a spontaneous ability to take action and have goal-directed behavior.
    • Processing speed = speed of scanning, reading, writing, and reasoning. This is the ability to perform these tasks when high mental concentration is required.
  • Zembrin showed an increase in cognitive flexibility, executive function, and processing speed.

These results provide evidence that Zembrin has the potential to improve quality of life of healthy people who may have cognitive functions compromised due to daily stress.

Zembrin is the first of its kind of Sceletium supplement and holds several distinctions:

  • Only patented Sceletium in the world.
  • Only legal source of supply through a biodiversity initiative.
  • Only standardized proprietary seed, plants, and extract.
  • Only Sceletium export permit granted (Permit No. IEP 0001) from the South African government in recognition of the producer's socially responsible and environmentally sustainable practices. Royalties from the sale of Zembrin will be paid to the South African San Council, with 50% guaranteed to be distributed to the Paulshoek and Nourivier communities.
  • Only Sceletium with the seal of endorsement by the San Tribesmen.
  • Only Sceletium authorized under license for commercialization in the USA.
  • All studies, safety data, claims, patents, bioprospecting permits, and export permits will be related to the proprietary standardized extract Zembrin and is not applicable to other forms of Sceletium.

KSM-66® Ashwagandha

Ashwagandha is a popular Indian plant that has been used in Ayurvedic medical tradition for its adaptogenic and strengthening properties for thousands of years. It has been traditionally used to help the body to cope with the effects of stress, tension, and fatigue.

The beneficial effects of ashwagandha come from the complex synergy of all its natural constituents and KSM-66 is a full-spectrum root-only extract, retaining all the natural constituents.

In a double-blind, randomized, placebo-controlled trial, subjects taking KSM-66 had a 27.9% reduction in levels of cortisol—a primary stress hormone—after 60 days, while placebo had a 7.9% reduction. Subjects were then given well-recognized psychological questionnaire tests to measure the effect of KSM-66. Test scores showed a significant 44% reduction in stress and a tremendous 75.6% reduction in anxiousness!3

In a prospective, double-blind, randomized placebo-controlled trial, 50 healthy athletic adults received either 600 mg/d (300 mg twice daily) of KSM-66 or placebo over 12 weeks to evaluate the efficacy of KSM-66 on cardiorespiratory endurance and quality of life. Data collected at baseline, day 28, 56, and 84.4

  • Cardiorespiratory endurance (VO2 max measures translated from 20-meter shuttle run): VO2 max as measurement determines an athlete's ability to take in, transport, and utilize oxygen.
  • KSM-66 resulted in a significant increase in maximum oxygen consumption (VO2 max) at Day 56 and Day 84 as compared to baseline.
  • KSM-66 was able to help support cardiorespiratory performance in healthy adults while helping to improve their perception of their quality of life.

B Vitamins (Vitamins B6, B12, and Quatrefolic® folic acid)

Folic acid and vitamins B6 and B12 are members of the B-vitamin complex that reduce homocysteine levels by "methylating" it, which involves attaching one carbon atom and three hydrogen atoms.

Vitamin B6 is involved in over 100 different enzymatic reactions in the body mostly involving the metabolism of proteins, carbohydrates, and fat.

B6 is also important for neural functioning and cognitive development. It is involved in the transmission of nerve impulses and is required for the production of serotonin and dopamine—neurotransmitters associated with mood and motivation.

Vitamin B12 is essential for brain and central nervous system functioning. B12 supports the synthesis of myelin (the sheath that protects the nerve axon and helps conductivity).

Together, these potent B vitamins…

  • Promote normal homocysteine levels for optimal cognitive function
  • Support healthy neuro-function
  • Support nerve transmission
  • Support healthy nerves
  • Support brain cell communication
  • Help reduce mental fatigue

1 Gericke N, Viljoen AM. J Ethnopharmacol. 2008;119(3):653–63.
2 Harvey AL, et al. J Ethnopharmacol. 2011;137(3):1124–29.
3 Chandrasekhar K, et al. Indian J Psychol. Med 2012;34(3):255–62.
4 Choudhary SB, et al. Ixoreal BioMed study.

Product Quality

  • Manufactured to exacting standards using highest quality raw materials
  • Produced in accordance with our strict Standard Operating Procedures (SOPs) that meet or exceed those set by the FDA’s Good Manufacturing Practices
  • Every batch tested to verify purity and potency specifications are met
  • Details of specific product testing is listed in the Certificate of Quality
  • Quality assured with our Triple-Testing Philosophy™
  • Backed by our 100% satisfaction guarantee