Daily support for an even, balanced mood

Zembrin® (30 capsules, 30-day supply) | Mood Vitamins & Supplements

Item# ZEM
1 Bottle
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Ancient African discovery quickly lifts your mood and keeps you motivated.

  • Quickly elevates your mood
  • Combats stress, anxiety, and tension
  • Increases attention, focus, motivation, and concentration
  • Non-habit forming and non-drowsy

You know when your mood isn’t as bright as it usually is. Maybe you’re feeling stressed and overwhelmed, which ultimately makes you grouchy, unmotivated, and foggy-headed.

Zembrin® will quickly lift your mood and increase your focus and attention. I’ve spent years searching for a safe, natural mood lifter that I trust 100% and highly recommend. I was thrilled when I discovered Zembrin, the only patented extract of Sceletium tortuosum, a succulent plant known by the San Bushmen people of South Africa as "kanna."

For centuries, the San Bushmen have traditionally used Sceletium plants to enhance mood, relieve stress and anxiety, and combat fatigue. They’ve even used the plants to relieve thirst and hunger and soothe colicky babies. Zembrin, a unique extract of carefully selected Sceletium plants, increases the levels of serotonin and serotonin neurotransmission, which explains why it has been a favorite of the San Bushmen for hundreds of years.

Zembrin’s alkaloids also inhibit phosphodiesterase 4 (PDE4), an enzyme in the body that regulates an important messenger substance in the cells of the nervous and immune systems called cAMP. By inhibiting PDE4, more cAMP is available, which has been shown to produce beneficial effects on mood in stressful situations.

Greater attention, focus, and motivation

Plus, Zembrin has been clinically shown to enhance cognitive function. In a randomized, double-blind clinical study, those taking 25 mg of Zembrin showed increased attention, focus, motivation, and concentration compared to a placebo. Best of all, there’s no evidence of tolerance or negative side effects. You get the full research dose in my Zembrin formula.

SA San Council Endorsement ZembrinOne of the only sources delivered right to your door

What makes Zembrin so unique is that it’s the only patented Sceletium in the world and the only legal source of supply. Plus, Zembrin is the only Sceletium endorsed by the San Bushmen. It’s extremely difficult to get access to. In fact, my Zembrin formula is one of the ONLY sources of Zembrin.

If stress and anxiety affect your mood and compromise your ability to think clearly and stay focused, I highly encourage you to give Zembrin a try. The small capsule is super easy to take every day. I have taken Zembrin myself and found that you’ll quickly notice a difference in your mood and ability to focus, concentrate, and make clearer decisions. I guarantee your quality of life will improve.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Ingredients and Dosage

Doctor's Suggested Use: Take 1 capsule daily.

Serving Size: 1 Capsule
Servings Per Container: 30

Ingredient Amount Per Serving % DV
Zembrin®‡ (Sceletium tortuosum extract, stem and leaf) 25 mg *
*Daily Value (DV) not established.

Other ingredients: Microcrystalline cellulose, gelatin, magnesium stearate, silicon dioxide

Note: Pregnant or lactating women should consult a health care professional before taking this product.
Keep out of reach of children.

® is the exclusive trademark of HG&H Pharmaceuticals (Pty) Limited, exclusively distributed in the USA by P.L. Thomas & Co., Inc.


Displaying 1-10 of 34

Reviewed on
5.0 out of 5 stars

I have to say that I've tried different vitamins, etc for mood before & these little capsules ended up being "it" for me! I am so much more focused & feel like I want to get up in the morning & see what the day brings. It did take a couple of weeks to feel the effect, which was not a big bomb but more of a subtle shift of emotions. It has helped me have more patience in my relationships & just feel like my old self again. I am so thrilled to have come across Dr. Williams. I also love when there is the 30% off code, that's when I stock up. oh yeah, my husband was taking some other emotional wellness vitamin from another company & we thought that was great, but now I started him on these vitamins & they are also working for him big time...Can't recommend highly enough!!

Reviewed on
5.0 out of 5 stars

i love Zembrin! There is no 'drugged' feeling, you just feel BETTER! how did i ever do without this product?

Reviewed on
5.0 out of 5 stars

This is a great product!

Reviewed on
3.0 out of 5 stars

I found it to be pretty interesting..I take [a prescription antidepressant] in the morning..only 5 mill..but did without it for a few days with you product..its promising

Reviewed on
5.0 out of 5 stars

An excellent herbal anti-depressant, which is also very effective for the treatment of anxiety, too. 'Kanna' is a natural sleep-aid for occasional insomnia, as well. It is one of the most potent herbs I've ever used for this complaint. The best part about using this herbal, organically-grown supplement is that there are NO SIDE EFFECTS!

Reviewed on
5.0 out of 5 stars

I began taking this product right before the holidays and noticed very quickly that it helped ease the stress during the busiest time of the year. I have been on it for about 4 months now and I can truly say that I have felt more calm, motivated, less stressed, positive and happy. I find that I can handle the daily annoyances in my life -work, traffic, family drama-much better. It helps get me through my day feeling focused and able to get things done, both at work and at home. And while I was never one to be prone to mood issues, I think this product keeps me feeling GREAT with sharper, clearer thinking.

Reviewed on
2.0 out of 5 stars

It's very difficult to determine if a change in mood is a result of a little pill one takes. Do I like Zembright Mood? Well yes, though No light goes on, no guage reflects a positive outcome, I can only judge by my 30 days experience with ZemBright Mood. Before I began, I was lazy, listless, fairly depressed and could not seem to start on any project I had pending. I was frustrated, easily angered and discouraged all the time. Over the past month, I have completed several major projects, like my taxes...and I have become more upbeat. I am far less discouraged and much more patient. I'm finally exercising regularly and just feel quite a bit better. Does ZemBright Mood account for this? Let's see what the next 30 days bring. If this product is truly the blessing it seems to be, I'm only sorry Dr Williams new ZemBright Plus wasn't available before I ordered my Zembright Mood. If I could be sure Zembright was really helping me pull myself out of the muck, it would have received 5 stars instead of 4.

Reviewed on
5.0 out of 5 stars

I seldom sang to myself and never out loud, before I tried ZemBright. Starting on the first day I took it, I found myself singing happily. That lasted a few weeks and now I'm down to singing just occasionally, but I generally feel better, happier. I've taken it every day for probably 6 months and it's made a big difference for me. I'm less anxious and angry now, more calm and able to take things in stride.

Reviewed on
1.0 out of 5 stars

Honestly, we got almost no effect at all (good or bad) from this product

Reviewed on
5.0 out of 5 stars

ZemBright has been very helpful during the dark time of the year. In the past years, I have been very lethargic, tired and depressed but since I started to take ZemBright a couple of months ago, I have been in steady energy and rather light mood. Of course, I also take several other Dr. Williams' products, so together they brighten and energize my life (Daily Advantage, Royal Bee, Probiotic and Vision Advantage). I am very grateful for Dr. Williams' life long dedication to enhance my life with the newest discoveries from the far away places. Thank you Dr. Williams!

Science and Quality

Traditional Use of Sceletium

  • Plants of the genus Sceletium were used for relief of thirst and hunger, to combat fatigue, as medicines, and for social and spiritual purposes by the San hunter-gatherers (historically referred to as Bushmen) and Khoi pastoralists (historically referred to as Hottentots) for millennia before the earliest written reports of the uses of the these plants by European explorers and settlers.1
  • Also called kanna, channa, or kougoed, Sceletium has been used by the indigenous San people for relaxation, stress relief, to promote sleep, and even to soothe colicky and teething infants for thousands of years. There is no documented or oral evidence that its use causes tolerance or addiction, and there is no withdrawal during periods of scarcity.
  • Since 1685, European settlers have recorded the use of Sceletium, calling it a “restorative, cheerer of the soul,” a “good sedative,” a calming herb, and (an herb or plant) that elevates mood and decreases anxiety, stress, and tension.


  • Zembrin is a standardized extract produced from an in-house elite proprietary plant selection of Sceletium tortuosum and contains a mix of the most desirable actives based on 12 years of research and development. Zembrin is standardized to 4 major alkaloids.
  • In vitro studies show potential mechanisms for how Sceletium may be used in products for stress, anxiety, and mood and may also provide a rationale for the apparent lack of dependence seen with long-term Sceletium use. Sceletium has been shown to act as a PDE4 inhibitor and as a serotonin-uptake inhibitor.2
  • Serotonin is one of the major neurotransmitters in the body. It plays an important role in sleep, pain thresholds, blood clotting, heartbeat, blood vessel constriction, libido, hunger/satiety, and mood. There are 17 types of serotonin receptors found all over the body, each causing different biological effects.
  • Serotonin reuptake inhibitors block the action of the serotonin transporter, increasing intracellular levels of serotonin and increasing serotonin neurotransmission. Specific constituents of Zembrin are known serotonin reuptake inhibitors (SRIs), which explains the traditional use of Zembrin as a mood lifter.
  • A randomized, double-blind, placebo-controlled crossover clinical study examined how Zembrin can help manage the stresses of everyday life by enhancing cognitive function.
    • 20 healthy adults were used in the study. They were divided into two groups: Placebo or Zembrin. They were given 25 mg of Zembrin or a placebo daily for 3 weeks. Then they had a 3 week washout period (no capsules). Then the groups were switched and given either placebo or Zembrin for 3 weeks.
    • The VitalSign® test was used to evaluate 10 different types of neuropsychological behavior at the end of each 3 weeks of treatment.
    • There were no side effects. No nausea or vomiting and no elevated pulse, blood pressure, or body weight.
    • The subjects taking Zembrin had significant changes (compared to placebo) in 3 out of the 10 VitalSign® tests: cognitive set flexibility, executive function, and processing speed.
      • Cognitive set flexibility = being able to adapt rapidly to changing directions and use the information given intelligently. This is necessary in decision-making, impulse control, and planning/strategizing.
      • Executive function = exercising initiative, judgment, and discipline. This is a spontaneous ability to take action and have goal-directed behavior.
      • Processing speed = speed of scanning, reading, writing, and reasoning. This is the ability to perform these tasks when high mental concentration is required.
    • Zembrin showed a 21.5% increase in cognitive flexibility, a 20.2% increase in executive function, and a 29.3% increase in processing speed.
  • These results provide evidence that Zembrin has the potential to improve quality of life of healthy people who may have cognitive functions compromised due to daily stress.
  • Zembrin is the first of its kind of Sceletium supplement and holds several distinctions:
    • Only patented Sceletium in the world.
    • Only legal source of supply through a biodiversity initiative.
    • Only standardized proprietary seed, plants, and extract.
    • Only Sceletium export permit granted (Permit No. IEP 0001) from the South African government in recognition of the producer’s socially responsible and environmentally sustainable practices. Royalties from the sale of Zembrin will be paid to the South African San Council, with 50% guaranteed to be distributed to the Paulshoek and Nourivier communities.
    • Only Sceletium with the seal of endorsement by the San Bushmen.
    • Only Sceletium authorized under license for commercialization in the USA.
    • All studies, safety data, claims, patents, bioprospecting permits, and export permits will be related to the proprietary standardized extract Zembrin and is not applicable to other forms of Sceletium.

1 Gericke N and Viljoen AM. J Ethnopharmacology. 2008;119:653–663.
2 Harvey AL, et al. J Ethnopharmacology. 2011;137:1124–1129.

Product Quality